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The cystic fibrosis drug Orkambi can help people with specific genetic mutations breathe better, but treatment with the pill comes with a hefty sticker price — $259,000 a year.

Orkambi, which was approved by the Food and Drug Administration last July, is expected to take almost $36 million from California's general fund this fiscal year and next. That cost estimate doesn't include any discounts the state may receive from drug manufacturers.

The Zika virus has gone from an obscure disease to an international public health emergency.

Genetics researchers often discover certain snips and pieces of the human genome that are important for health and development, such as the genetic mutations that cause cystic fibrosis or sickle cell anemia. And scientists noticed that genetic variants are more common in some races, which makes it seem like race is important in genetics research.

The decision by Hillary Clinton to use a private email server as secretary of state has spawned an FBI investigation, multiple congressional inquiries and dozens of private lawsuits that demand copies of her messages. It's also become an issue in her bid for the Democratic presidential nomination.

Republicans on the campaign trail have raised the prospect that Clinton could be charged with a crime — even as she downplays the FBI probe and asserts she wants voters to be able to see all of her messages from that time.

BMX rider Dave Mirra, who for years dominated his sport even as he helped others embrace it, has died at age 41. Police in Greenville, N.C., say they found Mirra "sitting in a truck with an apparent self-inflicted gunshot wound."

Police found Mirra in a parked vehicle shortly after he had visited friends in Greenville, where he had lived for years as an active member of the community. Mirra is survived by his wife and two daughters.

U.S. officials say there's no need for alarm over reports from Brazil out Friday that active Zika virus has been found in saliva and urine samples. Mosquitoes remain the primary source of Zika, and there's no proof that saliva and urine can transmit the virus, even if it is present there. Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, talks with Mary Louise Kelly about how the Zika virus may spread.

The New York City Fire Department says a crane collapse early Friday in Manhattan's Tribeca neighborhood killed at least one person, seriously injured two others and left another with minor injuries.

The Associated Press reported that the person killed was a Wall Street worker sitting in a parked car.

Fire officials tweeted that they sent more than 140 fire and emergency medical services personnel from more than 40 units to the scene at the intersection of Worth Street and West Broadway.

This week's show had our toes tapping, you can believe that.

At the beginning of The Club, four men and a woman are living quietly in a small Chilean seaside town. Their days are filled with prayer and religious songs, but also wine and greyhound racing.

Before they got down to debating the big issues Thursday night, Hillary Clinton and Bernie Sanders wrangled over one big word: progressivism.

Which of them was the true progressive? Was Clinton a progressive at all?

Sanders has long billed himself as a progressive, also describing himself as a "democratic socialist." He has not been known for flirting with the term "moderate." But Clinton has at times willingly chosen the latter label.

The U.S. economy added just 151,000 jobs in January while unemployment dropped slightly, to 4.9 percent, according to the latest figures from the Bureau of Labor Statistics.

Economists had expected to see about 190,000 new jobs.

The unemployment rate, which has held steady at 5 percent the past few months, dropped slightly to 4.9 percent. It's the first time unemployment has fallen below 5 percent since the recession.

The pope and the head of the Russian Orthodox Church will meet next week in Cuba for a two-hour session that the Vatican and the Moscow Patriarchate say would be "the first in history" — the churches split in the Great Schism of 1054.

The historic meeting between Pope Francis and Patriarch Kirill is set for Feb. 12. It's the result of an "intersection of the itineraries" as both leaders will be visiting Latin America next week, the Russian Orthodox Church says.

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Billy The Kid Is On The Loose

Feb 5, 2016
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The fifth debate between Hillary Clinton and Bernie Sanders was their first appearance as a duet, and that helped to highlight some of their harmony – even as it heightened their crescendos of dissonance.

With Martin O'Malley having suspended his campaign earlier in the week, the two remaining rivals for the Democratic presidential nomination met in New Hampshire on Thursday night — on stage together for nearly two hours.

"I happen to respect the secretary very much; I hope it's mutual," said Sanders.

And Clinton reciprocated:

WikiLeaks founder Julian Assange has been "arbitrarily detained" by Sweden and the U.K., a U.N. panel has ruled, adding that Assange should be freed and compensated for his treatment.

When Yann Martel gave us the international sensation Life of Pi in 2001, readers discovered a novelist-alchemist, capable of spinning gold out of improbable characters and anomalous scenarios. A tiger and a teenager awash together on the deep blue sea for 227 days? Only Martel could charm us into that suspension of disbelief, making the unlikely tale into fable rather than fluff.

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In a year where so many Republican voters are angry at Washington, it can be tough to have two former presidents in your family.

Former Florida Gov. Jeb Bush has struggled with that dynamic his entire campaign — sometimes embracing the Bush legacy, and sometimes holding it at arm's length. (The campaign logo is Jeb!, not Bush!)

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Sunday's Super Bowl 50 — Carolina Panthers versus the Denver Broncos — could mark the end of an era.

Peyton Manning's last game.

The veteran Broncos quarterback turns 40 next month. After a season plagued by injury and poor play, many suggested it was time to retire. Manning fueled speculation about his future after Denver won the AFC Championship game and microphones heard him tell New England head coach Bill Belichick, "This may be my last rodeo."

Ebrahim Pourfaraj wants to build the biggest hotel in all of Iran.

He's already started his project in the far north Tehran, a wealthy zone where the city climbs up the slopes of the snow-capped Alborz Mountains.

You get out of the car, carefully stepping over the little mountain stream that flows in a channel beside the curb. After stepping through a construction trailer, you emerge on a steel-mesh platform looking over the edge of an enormous hole.

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The fifth Democratic debate was the first mano-a-mano encounter of the campaign. It meant there was enough room for an extended argument over the word "progressive." The biggest clash came when Sanders accused Clinton of taking Wall Street money. Clinton fired back that it was time to end that "artful smear." Sanders again turned talk of foreign policy to questioning Clinton's "judgment" on the Iraq War. Clinton replied: "A vote in 2002 is not a plan to defeat ISIS." Sanders refused to politicize the email issue.

The fight over the definition of "progressive" dominated the first half of Thursday's debate between Hillary Clinton and Bernie Sanders on MSNBC, the first head-to-head debate between the two. It came just days before the crucial New Hampshire primary.

Here are seven moments that stood out:

1. "A progressive is someone who makes progress."

The debate focused on a central question about what it means to be a Democrat in 2016.

"A progressive is someone who makes progress," Clinton said.

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The founder of Earth, Wind and Fire has died. Maurice White has Parkinson's disease for many years. He died at his home here in Los Angeles at the age of 74. NPR's Ted Robbins has this appreciation.

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