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By the time DeAngelo Cortijo was 14, he had been in more than a dozen foster homes. He had run away and lived on the streets for months, and he had been diagnosed with bipolar and anxiety disorders, attachment disorder, intermittent explosive disorder or posttraumatic stress disorder. He had been in and out of mental hospitals and heavily medicated.

Cortijo, who was born in San Francisco, was taken from his mother after she attempted suicide when he was 3.

U.S. Attorney General Loretta Lynch has strongly condemned shootings of law enforcement officers in Texas and Illinois and issued an unequivocal message of support for police.

"We have had four more guardians slain, and frankly our hearts are broken," the attorney general said Wednesday in remarks to a fair housing conference in Washington, D.C. "I offer the families of these officers my condolences, and I ask that all of us come together and keep them in our prayers."

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Maryland Sen. Barbara Mikulski announced Wednesday that she will support the Iran nuclear agreement, giving the White House the final vote needed to protect the accord from a Republican-led effort to defeat the measure.

With her endorsement, Mikulski became the crucial 34th vote needed to sustain President Obama's expected veto should Congress pass a measure to block the agreement.

In a statement, Mikulski says:

A recent outbreak of Salmonella in frozen tuna might have sushi lovers wondering if it's safe to eat that raw fish.

The outbreak in question began in California in March. All told, it sickened 65 people in 11 states. There were 35 cases in California, with another 18 in Arizona and New Mexico. The rest of the cases were scattered across the country, including four in Minnesota.

Update at 11:52 a.m. ET. Judge Denies Two Key Motions:

A judge in Baltimore handed prosecutors two pretrial victories on Wednesday in relation to the Freddie Gray case, a 25-year-old man who died after suffering injuries in police custody.

NPR's Jennifer Ludden reports that the judge rejected a motion to dismiss charges against six police officers who were allegedly involved in Gray's arrest and death. And the judge also dismissed a motion that sought to remove Baltimore State's Attorney Marilyn Mosby from the case.

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Updated 12:08 p.m. ET: Uber Responds

Uber has been fighting challenges to its business model. But a federal judge in California has allowed some drivers to proceed with a class-action lawsuit against the ride-hailing service. The case could affect other big companies in the sharing economy.

Uber challenged the traditional taxi business with an app that brought together people who need a ride with people who have cars. The drivers get paid a rate set by Uber.

For a second day, thousands of stranded migrants, including refugees from Syria, Afghanistan and Iraq, have camped out at the main train station in Budapest.

As we've reported, the Hungarian government was allowing the migrants to leave without a passport check, but on Tuesday migrants were barred from boarding trains that were headed toward Western Europe.

Reporting from the Keleti Railway Station in Budapest, Joanna Kakissis tells our Newscast unit that the train station has become the latest flashpoint in this migrant crisis. She filed this report:

This post was updated at 10:30 a.m. ET

Congress votes on President Obama's nuclear deal with Iran this month. Most lawmakers have said they oppose the deal, yet he has a good chance of winning.

That is because the deal will be considered under rules that favor him, even if only a minority supports him in Congress.

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On Wednesday, in honor of footballs that are inflated, we must discuss extra points. The NFL is monkeying around with the extra point again. You think it should? Do you have a better idea? Do we even need an extra point? Why do we have an extra point?

Well, the extra point is vestigial, a leftover from the good old 19th century days when football had identity problems and couldn't decide whether or not it was rugby. Or something. At that point, in fact, what was sort of the extra point counted more than the touchdown itself.

More adults across the country are strapping on helmets and hopping on bikes to get to work. That's good news for people's hearts and waistlines, but it also means more visits to the emergency room.

Hospital admissions because of bike injuries more than doubled between 1998 and 2013, doctors reported Tuesday in JAMA, the journal of the American Medical Association. And the rise was the biggest with bikers ages 45 and over.

Kentucky's Gov. Steve Beshear says he's powerless to stop Rowan County Clerk Kim Davis from refusing to issue marriage licenses to same-sex couples – something she has done for consecutive days, flouting rulings from federal courts that include the Supreme Court and prompting a motion to hold her in contempt of court.

The federal trial of a Madison Police Department officer accused of using excessive force on an unarmed Indian man began in Huntsville Tuesday.

Madison Police Department officer Eric Parker is charged with violating the civil rights of Sureshbhai Patel, an unarmed 57-year-old Indian man, during a daytime confrontation in February. The encounter was caught on a police cruiser dash cam video. Patel is seen being forcefully swept off his feet and slammed to the ground, causing severe injuries.

The incident sparked an international outcry.

Carly Fiorina was relegated to the JV squad in the Fox News GOP presidential debate in August, but her strong performance that night helped her race past several of her peers in recent polls.

That surge in polling wasn't enough to get her into the next big debate — but it might be now.

That's because CNN Tuesday afternoon changed its criteria for who will get into its main Sept. 16 debate in such a way that Fiorina is much more likely to be included.

Both the Nasdaq and the Dow Jones index were hit by losses Tuesday, as concerns again rose about China's economy. The Dow is now down nearly 10 percent in 2015, after falling 469 points Tuesday to close at 16,058.

Markets in Europe and Asia also suffered, after renewed worries about a slowdown in China, the world's second-largest economy.

"The latest evidence is China's purchasing manager's index," NPR's John Ydstie reports, "which shows the country's manufacturing sector contracting."

The largest fish farm in America could be built 4 miles off San Diego's coast.

Rose Canyon Fisheries could have a footprint on the ocean floor of 1.3 square miles, about the same size as New York's Central Park. The goal is to produce 11 million pounds of yellowtail and sea bass each year.

More than a month after his trial on murder charges ended in a mistrial for the second time, former Eutawville, S.C., police Chief Richard Combs has been sentenced to a year of home detention. Combs agreed to plead guilty to misconduct in office Tuesday.

Combs, who is white, was the head of the police department in the small town of Eutawville back in May 2011, when he shot and killed 54-year-old Bernard Bailey, who was black, as Bailey tried to drive away from the Eutawville Police Department.

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Transcript

ROBERT SIEGEL, HOST:

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Transcript

ROBERT SIEGEL, HOST:

Katherine Franke is a law professor at Columbia University where she heads the Public Rights/Private Conscience Project. And she joins us from New York to talk about this some more. Welcome to the program.

Take a trip to The Mob Museum in Las Vegas and you'll find exhibits on gangsters, corruption, killers, crime bosses, drug traffickers — and, now, the international governing body of soccer.

Tuesday, the much maligned FIFA Congress finds itself alongside the likes of the Mafia and drug cartels, thanks to the opening of a new, temporary exhibit called "The 'Beautiful Game' Turns Ugly."

In her third year of medical school, Karen Duong found herself on the other side of Texas. She had driven 12 hours north from where she grew up on the Gulf Coast to a panhandle town called Hereford.

"Hereford is known for being the beef capital of the world," she says, laughing. "There's definitely more cows than people out there."

In the latest high-profile change for the Tokyo 2020 Olympic and Paralympic Games, organizers withdrew their games' official logo Tuesday, after weeks of heavy criticism. A graphic designer had filed a lawsuit over the resemblance to his own work.

Belgian designer Olivier Debie first complained about the logo soon after it was unveiled in July, saying the image presented by Japanese designer Kenjiro Sano was too similar to one he created for the Theatre de Liège in 2011. Debie had noted that his logo was widely shared on Pinterest.

California authorities have agreed to sharply limit the number of inmates held in isolation for long periods of time, a major development in the national debate about solitary confinement.

The agreement resolves a class-action lawsuit filed by prisoners who say the practice amounts to cruel and unusual punishment. Advocates say it could change the daily lives of as many as 2,000 inmates stuck in isolation because authorities determined they had some ties to a gang.

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